Ipamorelin is a highly selective pentapeptide GHSR (ghrelin receptor) agonist widely referenced in published GH-axis research. This is the full New Zealand ipamorelin peptide profile — structure, PK, blend logic and analytical documentation.
The ipamorelin peptide is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH₂, ~711.9 Da) documented as one of the most receptor-selective growth-hormone secretagogues in the published literature. Unlike earlier GHRPs (GHRP-2, GHRP-6, hexarelin), rodent research on the ipamorelin peptide reports no measurable elevation of prolactin, ACTH or cortisol at studied doses — a selectivity profile that made ipamorelin a reference compound for isolated GH-axis studies.
New Zealand research groups typically reference the ipamorelin peptide alongside CJC-1295 (with or without DAC) because the two peptides engage complementary axes: GHRH (CJC-1295) and GHSR/ghrelin (ipamorelin). This profile documents the ipamorelin peptide at the level of detail needed for reproducible batch and PK worksheets.
Ipamorelin peptide structure
| Attribute | Specification |
|---|---|
| Sequence | Aib-His-D-2-Nal-D-Phe-Lys-NH₂ |
| Molecular weight | ~711.9 Da |
| Class | Pentapeptide growth-hormone secretagogue |
| Receptor target | Growth hormone secretagogue receptor (GHSR-1a / ghrelin receptor) |
| Published half-life | ~2 hours |
| Documented purity spec | ≥ 98% HPLC |
Ipamorelin vs earlier GHRPs (published selectivity)
| Compound | GH release | Prolactin | ACTH / cortisol |
|---|---|---|---|
| Ipamorelin | Marked | No measurable rise | No measurable rise |
| GHRP-2 | Marked | Modest | Modest |
| GHRP-6 | Moderate | Modest | Modest |
| Hexarelin | Marked | Elevated | Elevated |
Why the ipamorelin peptide is documented in GH-axis research
- Highly selective GHSR-1a activation with clean published receptor pharmacology.
- Reproducible PK across published rodent and in-vitro datasets.
- Canonical GHSR reference when pairing with GHRH analogs (CJC-1295, sermorelin, tesamorelin).
- Widely used as a comparator when characterising newer secretagogues.
Reconstitution reference (research use only)
| Vial size | Diluent (BAC water) | Concentration |
|---|---|---|
| 2 mg | 2 mL | 1000 mcg/mL |
| 5 mg | 2.5 mL | 2000 mcg/mL |
| 5 mg | 5 mL | 1000 mcg/mL |
- Batch identifier and synthesis date traceable to the lot record
- HPLC purity ≥98% (typically ≥99% for peptides under 30 residues)
- LC-MS confirmed monoisotopic or average mass within ±0.5 Da of theoretical
- Counterion identity and content (acetate or trifluoroacetate) reported
- Bacterial endotoxin and residual solvents per the analytical method
Ipamorelin peptide FAQ
What is the ipamorelin peptide?
Ipamorelin is a selective pentapeptide agonist of the growth-hormone secretagogue receptor (GHSR-1a), documented in published research for GH release without measurable prolactin or cortisol elevation.
How does ipamorelin differ from CJC-1295?
Ipamorelin acts on the GHSR (ghrelin) receptor; CJC-1295 acts on the GHRH receptor. The two are frequently blended because their mechanisms are independent and additive in published GH-axis models.
Is ipamorelin the same as a GHRP?
Ipamorelin is a growth-hormone-releasing peptide (GHRP) family compound, but with far higher receptor selectivity than earlier GHRP-2 and GHRP-6 references.
Where can I buy research-grade ipamorelin in New Zealand?
Kiwi Peps supplies ipamorelin at ≥98% HPLC purity with third-party COA and same-day domestic dispatch. Strictly for laboratory research use.
