The most cited GH secretagogue research blend: GHRH (CJC-1295) plus GHSR (ipamorelin) in a single reconstitution. Full mechanism, PK, ratios, reconstitution and COA reference for New Zealand laboratories.
The CJC-1295 + ipamorelin blend is the most frequently referenced growth-hormone secretagogue combination in published research. CJC-1295 activates the GHRH receptor on pituitary somatotrophs; ipamorelin activates the GHSR (ghrelin) receptor. Because the two signals converge on GH release through independent pathways, the CJC-1295 + ipamorelin blend produces an additive response documented across rodent and in-vitro literature.
New Zealand research groups typically order the CJC-1295 + ipamorelin blend pre-mixed to reduce pipetting error and preserve stoichiometry. This reference documents the two most common formats (no-DAC blend and DAC blend), reconstitution ratios and the analytical documentation expected on a batch COA.
Mechanism of the CJC-1295 + ipamorelin blend
| Component | Receptor | Axis |
|---|---|---|
| CJC-1295 (with or without DAC) | GHRH-R | GHRH stimulation on somatotrophs |
| Ipamorelin | GHSR-1a (ghrelin) | GHSR stimulation, no prolactin/cortisol confound |
Two common blend formats
| Format | Typical ratio | Kinetics | Reference use |
|---|---|---|---|
| Mod GRF 1-29 (no-DAC) + ipamorelin | 2 mg + 2 mg per vial | Pulsatile, short half-life | Pulse-based GH studies |
| CJC-1295 DAC + ipamorelin | 2 mg + 2 mg per vial | Sustained CJC + short ipamorelin | Steady-state exposure with acute pulse layer |
Why the CJC-1295 + ipamorelin blend is documented together
- Two independent axes — additive published GH response.
- Ipamorelin selectivity avoids prolactin/cortisol confounds seen with GHRP-6.
- Fixed-ratio pre-blend improves reproducibility across batch runs.
- Widely used as a benchmark comparator for newer secretagogue candidates.
Reconstitution reference
| Total vial | BAC water | Concentration per component |
|---|---|---|
| 2 mg + 2 mg | 2 mL | 1000 mcg/mL each |
| 5 mg + 5 mg | 5 mL | 1000 mcg/mL each |
- Batch identifier and synthesis date traceable to the lot record
- HPLC purity ≥98% (typically ≥99% for peptides under 30 residues)
- LC-MS confirmed monoisotopic or average mass within ±0.5 Da of theoretical
- Counterion identity and content (acetate or trifluoroacetate) reported
- Bacterial endotoxin and residual solvents per the analytical method
CJC-1295 + ipamorelin blend FAQ
Why blend CJC-1295 with ipamorelin?
The two compounds engage independent GH-axis receptors (GHRH and GHSR). Published research shows the combined signal is additive on GH release.
Should I use the DAC or no-DAC version of CJC-1295 in the blend?
No-DAC (Mod GRF 1-29) preserves pulsatile kinetics and is the more common blend choice. DAC blends are referenced when sustained exposure is required.
What ratio is documented for the CJC-1295 + ipamorelin blend?
Published research references typically use a 1:1 ratio (e.g. 2 mg + 2 mg per vial), reconstituted so each component yields 1000 mcg/mL.
Where can New Zealand researchers buy the CJC-1295 + ipamorelin blend?
Kiwi Peps supplies pre-blended CJC-1295 + ipamorelin at ≥98% HPLC purity with third-party COA and same-day domestic dispatch. Research use only.
