Sermorelin is the 29-residue N-terminal fragment of native GHRH — the short-acting reference compound for pulsatile GH-axis studies. Full Kiwi Peps research profile inside.
The sermorelin peptide corresponds to residues 1–29 of native human growth-hormone-releasing hormone (GHRH). Published research shows the first 29 residues carry the full biological activity of the parent 44-residue GHRH molecule, making the sermorelin peptide a natural benchmark for GHRH-axis studies. Its short published half-life makes it the canonical pulsatile-kinetics reference compound in the GHRH-analog family.
Sermorelin peptide at a glance
| Attribute | Specification |
|---|---|
| Sequence length | 29 residues (GHRH 1-29) |
| Molecular weight | ~3,358 Da |
| Receptor target | GHRH receptor (GHRHR) |
| Published half-life | ~10–20 minutes |
| Documented purity spec | ≥ 98% HPLC |
Sermorelin vs other GHRH-family research references
| Compound | Backbone | Half-life | Kinetic role |
|---|---|---|---|
| Sermorelin | GHRH 1-29 (native) | ~10–20 min | Pulsatile reference |
| Mod GRF 1-29 (CJC-1295 no-DAC) | GHRH 1-29 + 4 substitutions | ~30 min | Pulsatile, more stable |
| CJC-1295 with DAC | GHRH 1-29 + DAC linker | ~6–8 days | Sustained exposure |
| Tesamorelin | GHRH + hexenoic acid | Extended | DPP-4-resistant, long |
Why researchers reference the sermorelin peptide
- Native GHRH sequence — closest structural reference to endogenous ligand.
- Pulsatile PK preserves natural hormone-axis rhythm in study designs.
- Long publication history as a comparator for newer GHRH analogs.
- Straightforward reconstitution and dose-response mapping.
Reconstitution reference (research use only)
| Vial size | Diluent (BAC water) | Concentration |
|---|---|---|
| 2 mg | 2 mL | 1000 mcg/mL |
| 5 mg | 5 mL | 1000 mcg/mL |
- Batch identifier and synthesis date traceable to the lot record
- HPLC purity ≥98% (typically ≥99% for peptides under 30 residues)
- LC-MS confirmed monoisotopic or average mass within ±0.5 Da of theoretical
- Counterion identity and content (acetate or trifluoroacetate) reported
- Bacterial endotoxin and residual solvents per the analytical method
Sermorelin peptide FAQ
What is the sermorelin peptide?
Sermorelin is the 29-residue N-terminal fragment of native human GHRH — the biologically active portion of the endogenous hormone.
How does sermorelin differ from CJC-1295?
Sermorelin is the unmodified GHRH 1-29 sequence with a short half-life. CJC-1295 adds stabilising substitutions and, in its DAC form, an albumin-binding linker for a multi-day half-life.
How is sermorelin different from tesamorelin?
Tesamorelin adds an N-terminal trans-3-hexenoic acid moiety that resists DPP-4 cleavage. Sermorelin has no such modification and is documented as the shorter-acting reference.
Where can New Zealand researchers buy the sermorelin peptide?
Kiwi Peps supplies research-grade sermorelin at ≥98% HPLC purity with third-party COA and same-day domestic dispatch. Research use only.
