Melanotan 2 is a cyclic synthetic α-MSH analog studied across the melanocortin receptor family (MC1R–MC5R) in published in-vitro research. Full Kiwi Peps profile inside.
The Melanotan 2 peptide (MT-2, also written Melanotan II) is a cyclic heptapeptide analog of α-melanocyte-stimulating hormone (α-MSH) engineered for non-selective agonism across the melanocortin-receptor family (MC1R, MC3R, MC4R and MC5R). It is one of the most extensively characterised cyclic melanocortin research peptides in the published in-vitro literature, and a common reference compound in melanocortin receptor-selectivity comparison panels.
Melanotan 2 peptide at a glance
| Attribute | Specification |
|---|---|
| Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂ |
| Molecular weight | ~1,024.2 Da |
| Class | Cyclic α-MSH analog |
| Receptor targets | MC1R, MC3R, MC4R, MC5R (non-selective) |
| Documented purity spec | ≥ 98% HPLC |
Melanotan 2 vs PT-141 (bremelanotide)
| Attribute | Melanotan 2 | PT-141 |
|---|---|---|
| Structure | Cyclic heptapeptide | Melanotan-2-derived linear analog |
| Selectivity | Non-selective MC1–MC5R | MC4R-preferential |
| Reference research context | Melanocortin receptor panels | MC4R-selective behavioural models |
- Batch identifier and synthesis date traceable to the lot record
- HPLC purity ≥98% (typically ≥99% for peptides under 30 residues)
- LC-MS confirmed monoisotopic or average mass within ±0.5 Da of theoretical
- Counterion identity and content (acetate or trifluoroacetate) reported
- Bacterial endotoxin and residual solvents per the analytical method
Melanotan 2 peptide FAQ
What is the Melanotan 2 peptide?
Melanotan 2 is a cyclic heptapeptide α-MSH analog studied as a non-selective melanocortin-receptor reference across MC1R–MC5R in published in-vitro literature.
How is Melanotan 2 different from Melanotan 1?
Melanotan 1 (afamelanotide) is a linear α-MSH analog with different receptor kinetics; Melanotan 2 is cyclic and non-selective across the melanocortin family.
How does Melanotan 2 relate to PT-141?
PT-141 (bremelanotide) is a Melanotan-2-derived analog engineered for MC4R-preferential activity.
Where can New Zealand researchers buy the Melanotan 2 peptide?
Kiwi Peps supplies Melanotan 2 at ≥98% HPLC purity with third-party COA and same-day domestic dispatch. Research use only.
