AOD-9604 is a 17-residue fragment of human growth hormone studied in adipocyte culture for lipolytic signalling independent of the full GH receptor. In-vitro profile for NZ research.
The AOD-9604 peptide is a 17-residue synthetic peptide corresponding to the 176-191 C-terminal region of human growth hormone, with an added N-terminal tyrosine for solubility and analytical detection. It was engineered to isolate the lipolytic signalling of the hGH C-terminus for study in adipocyte culture models, separate from the full growth-hormone receptor cascade. This profile is strictly an in-vitro research reference.
What is AOD-9604?
AOD-9604 preserves the lipolytic C-terminal domain of human growth hormone (residues 176-191) with an added N-terminal tyrosine for improved handling and detection by mass spectrometry. In published in-vitro work it is studied for adipocyte β3-adrenergic-like signalling associated with increased lipolysis and reduced lipogenesis, while not measurably activating the classical hGH receptor or inducing IGF-1 in the same models.
AOD-9604 identity and specifications
| Attribute | Value |
|---|---|
| Full name | Tyr-hGH176-191 fragment |
| Origin | C-terminal fragment of human growth hormone |
| Length | 17 amino acid residues |
| Molecular formula | C78H123N23O23S2 |
| Average mass | ~1815 Da |
| Structural feature | Intramolecular disulfide bridge (Cys-Cys) |
| Format supplied | Lyophilised powder, research use only |
| Storage (lyophilised) | -20 °C, protected from moisture |
Mechanism studied in adipocyte culture
- β3-adrenergic-like signalling reported in adipocyte cultures alongside elevated lipolysis rates.
- Reduced lipogenesis reported in the same in-vitro models.
- No measurable IGF-1 induction reported — distinguishing AOD-9604 from full-length hGH or GHRH-analog research ligands.
- No measurable growth-hormone receptor activation in published binding assays, supporting its use as a receptor-selective research fragment.
Published in-vitro and structural literature
| Research focus | Assay type | Typical readout studied |
|---|---|---|
| Lipolysis signalling | Adipocyte culture (e.g. 3T3-L1) | Glycerol release / lipolysis rate |
| hGH-R activation | Receptor binding assay | Percent activation vs full-length hGH |
| IGF-1 induction | Hepatocyte or serum-marker assay | IGF-1 concentration change |
Handling and storage reference
- Supplied as lyophilised powder for reconstitution into assay buffer for laboratory research only.
- Lyophilised material: stable at -20 °C for 24+ months when protected from moisture.
- Reconstituted working solutions: store at 2–8 °C and use promptly within your own validated assay window.
- Avoid repeated freeze–thaw cycles to preserve peptide integrity.
AOD-9604 vs semaglutide: mechanism contrast
| Attribute | AOD-9604 | Semaglutide |
|---|---|---|
| Origin | hGH C-terminal fragment | GLP-1 analog |
| Receptor/pathway studied | Adipocyte β3-adrenergic-like signalling | GLP-1 receptor |
| Length | 17 residues | 31 residues |
| Average mass | ~1815 Da | ~4113.6 Da |
Certificate of analysis expectations
- Batch identifier and synthesis date traceable to the lot record
- HPLC purity ≥98% (typically ≥99% for peptides under 30 residues)
- LC-MS confirmed monoisotopic or average mass within ±0.5 Da of theoretical
- Counterion identity and content (acetate or trifluoroacetate) reported
- Bacterial endotoxin and residual solvents per the analytical method
Sourcing research AOD-9604 in New Zealand
Kiwi Peps supplies AOD-9604 verified to the KP-99 Purity Standard (99%+ HPLC-MS), with every batch recorded in The Batch Book. Orders cleared by 2pm NZT ship the same working day under Bench-Ready Dispatch, tracked nationwide with NZ Post CourierPost. Strictly for in-vitro research use only.
Frequently asked questions
What is AOD-9604 used for in research?
AOD-9604 is used in adipocyte-culture models to study lipolytic and anti-lipogenic signalling separate from the full growth-hormone receptor cascade.
Does AOD-9604 activate the growth hormone receptor?
Published binding assays report no measurable activation of the classical hGH receptor, distinguishing it from full-length hGH.
What is the molecular weight of AOD-9604?
AOD-9604 has an average molecular mass of approximately 1815 Da across its 17-residue sequence.
How is AOD-9604 supplied by Kiwi Peps?
As lyophilised powder verified to the KP-99 Purity Standard, with a HPLC-MS certificate of analysis in The Batch Book.
Is AOD-9604 approved for human use in New Zealand?
No. Kiwi Peps supplies AOD-9604 strictly as a research-use-only peptide for in-vitro laboratory work.
